Five patients were treated with gonadotropin and topical testosterone for micropenis associated with hypothalamic hypogonadotropic hypogonadism.
All patients received 1,000 units of gonadotropin weekly for three weeks, with a 6-week interval followed by 10% topical testosterone cream twice daily for three weeks. Serum testosterone levels were measured and remained equivalent for both modes of therapy.
The average penile growth response with gonadotropin was a 14.3% increase in length and a 5.0% increase in girth. Topical testosterone produced an average increase of 60% in penile length and 52.9% in girth. The most extraordinary growth response occurred in prepubertal male subjects, with a minimal reaction in postpubertal male subjects. This study suggests that 10% topical testosterone cream twice daily will produce effective penile growth. The response appears to be greater in younger children, consistent with previously published studies of age-related five reductase activity.
All patients received 1,000 units of gonadotropin weekly for three weeks, with a 6-week interval followed by 10% topical testosterone cream twice daily for three weeks. Serum testosterone levels were measured and remained equivalent for both modes of therapy.
The average penile growth response with gonadotropin was a 14.3% increase in length and a 5.0% increase in girth. Topical testosterone produced an average increase of 60% in penile length and 52.9% in girth. The most extraordinary growth response occurred in prepubertal male subjects, with a minimal reaction in postpubertal male subjects. This study suggests that 10% topical testosterone cream twice daily will produce effective penile growth. The response appears to be greater in younger children, consistent with previously published studies of age-related five reductase activity.
